Methyl 3-amino-2-{[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]amino}benzoate → HCID 15654678, compound

HRID 397121Notes

Reaction equation

HRID 397121 reaction equation
[NH2:1][C:2]1[C:3]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]#[N:27])=[CH:16][CH:15]=2)=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:28]([O-])([O-])([O-])[O:29][CH2:30][C:31]([F:34])([F:33])[F:32]>>[C:26]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:17]1[CH:18]=[CH:19][C:14]([CH2:13][N:12]2[C:3]3[C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:9][CH:10]=[CH:11][C:2]=3[N:1]=[C:28]2[O:29][CH2:30][C:31]([F:34])([F:33])[F:32])=[CH:15][CH:16]=1)#[N:27]

Participants

3

Reactant 2

HCID 15654653Methyl 3-amino-2-{[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]amino}benzoateHCID 86584013HCID 86584013, compound

Product 1

HCID 15654678HCID 15654678, compoundYield 25%

Procedure

The title compound was prepared as pale yellow crystals from methyl 3-amino-2-[[(2′-cyanobiphenyl-4-yl)methyl]amino]benzoate and 2,2,2-trifluoroethyl orthocarbonate according to the procedure for Working Example 3. Yield: 25%, m.p. 143-145° C.

Sources & evidence

ORD record
ord-e67348a600264e468670adcd0ce680b2
Source dataset
uspto-grants-2003_08
Patent number
US06608210B2

Reaction notes

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