Triethylamine → (3-Chloro-4-methanesulfonyl-phenyl)-diazo-acetic acid methyl ester

Participants

Reaction Steps

A solution of (3-chloro-4-methanesulfonyl-phenyl)-(4-toluenesulfonyl-hydrazono)-acetic acid methyl ester (3.82 g, 8.5 mmol) and triethylamine (1.3 mL, 9.35 mmol) in dichloromethane (40 mL) was stirred at 25° C. After 1 h, the reaction was evaporated under reduced pressure and the resulting residue was purified by flash chromatography (Merck Silica gel 60, 230-400 mesh, 60/40 hexanes/ethyl acetate) to give (3-chloro-4-methanesulfonyl-phenyl)-diazo-acetic acid methyl ester (978 mg, 40% yield) as a bright yellowish orange solid, mp 102.7-106.5° C.; EI-HRMS m/e calcd for C10H9N2ClSO4 (M+) 287.9972, found 287.9979.

Provenance & Evidence