Chlorosulfonyl isocyanate → HCID 15453237, compound

Participants

Reaction Conditions

Reaction Steps

30.9 g (75 mmol) of the compound of example IV or IVa are dissolved in 750 ml dichloromethane and cooled to 0°C. 11.6 g (82 mmol) chlorosulfonyl isocyanate in dichloromethane are added and the mixture is stirred at 0° C. for 30 min and at room temperature for 3 h. The solvent is removed in vacuo, the residue suspended in water and stirred vigorously for 3 h at 60° C. After cooling to r.t. the suspension is filtered, the crude product dried in a desiccator in the presence of phosphorus pentoxide and triturated with diisopropylether at 40° C.;.

Provenance & Evidence