Water → HCID 70020861, compound

Participants

Reaction Steps

To a solution of 4-(2-methylsulfinylpyrimidinyl)methyl-4-fluorophenylketone (5.7 mmol) in 75 mL THF was added 22 mL of 25% NaOMe in MeOH at 0° C. The solution was warmed to room temperature and stirred for 1 h. The solution was then heated at 50° C. for 30 min. Next, the solution was cooled, 200 mL of H2O were added and it was extracted thrice with 100 mL of ethyl acetate. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to give a solid. The solid was then purified by silica gel chromatography with 15-30% ethyl acetate/hexane to give the title compound as a light yellow solid (0.8 g, 57%). ES(+)MS m/e=247 (MH+)

Provenance & Evidence