Triethyl phosphite → HCID 12087790, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[4-(N,N-Dimethylaminomethyl)phenyl]-4-(4-fluorophenyl)-5-(2-phenoxy-4-pyrimidinyl)imidazole-N-oxide (0.32 g, 0.66 mmol) in 5 mL of N,N-dimethylacetamide was added triethyl phosphite (0.34 mL, 2.0 mmol) and the solution was heated at 95° C. overnight. The solution was concentrated to a small volume under reduced pressure and H2O was added. The mixture was extracted thrice with 20 mL of CH2C2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to give a yellow oil. The oil was purified by silica gel chromatography using 5-15% CH3OH/CH2Cl2 to give the title compound as a yellow foam (0.094 g, 30%). ES(+)MS m/e=466 (MH+)

Provenance & Evidence