3,5-Dimethyl-1H-pyrrole-2-carbaldehyde → HCID 73885145, compound

HRID 397387Notes

Reaction equation

HRID 397387 reaction equation
[Cl:1][C:2]1[C:3]2[CH2:10][C:9](=[O:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:12][C:13]1[CH:17]=[C:16]([CH3:18])[NH:15][C:14]=1[CH:19]=O>>[Cl:1][C:2]1[C:3]2[C:10](=[CH:19][C:14]3[NH:15][C:16]([CH3:18])=[CH:17][C:13]=3[CH3:12])[C:9](=[O:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 2704653,5-Dimethyl-1H-pyrrole-2-carbaldehydeHCID 120958704-chloro-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one

Product 1

HCID 73885145HCID 73885145, compoundYield 44.5%

Procedure

4-Chloro-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (1 eq.) was condensed with 3,5-dimethyl-1H-pyrrole-2-carbaldehyde (1 eq.) at room temperature to give (44.5%) of 4-chloro-5-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one.

Sources & evidence

ORD record
ord-2abae44277fc47449395b2ce36c28376
Source dataset
uspto-grants-2003_08
Patent number
US06610688B2

Reaction notes

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