Morpholine → HCID 178433260, compound

HRID 397392Notes

Reaction equation

HRID 397392 reaction equation
Cl[C:2]1[C:3]2[C:10](=[CH:11][C:12]3[NH:13][CH:14]=[N:15][C:16]=3[CH3:17])[C:9](=[O:18])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>C(O)C>[CH3:17][C:16]1[N:15]=[CH:14][NH:13][C:12]=1[CH:11]=[C:10]1[C:3]2[C:2]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[N:7][CH:6]=[N:5][C:4]=2[NH:8][C:9]1=[O:18]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 178433258HCID 178433258, compound

Product 1

HCID 178433260HCID 178433260, compoundYield 70.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-chloro-5-(5-methyl-3H-imidazol-4-ylmethylene)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (26 mg, 0.1 mmol) and morpholine (100 mg, 1.15 mmol) in ethanol (1.5 mL) was heated in a sealed tube at 110° C. for 3 hours. The reaction solution was evaporated to dryness and treated with cold ethanol. The yellow precipitate was filtered to give 22 mg (70.5%) of the title compound. MS-EI 312 [M+].

Workup

  1. customThe reaction solution was evaporated to dryness
  2. additiontreated with cold ethanol
  3. filtrationThe yellow precipitate was filtered

Sources & evidence

ORD record
ord-06d530cffce94aff903b7f4c82c3d0b1
Source dataset
uspto-grants-2003_08
Patent number
US06610688B2

Reaction notes

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