反应详情

温度

110 °C

A mixture of 4-chloro-5-(5-methyl-3H-imidazol-4-ylmethylene)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (26 mg, 0.1 mmol) and morpholine (100 mg, 1.15 mmol) in ethanol (1.5 mL) was heated in a sealed tube at 110° C. for 3 hours. The reaction solution was evaporated to dryness and treated with cold ethanol. The yellow precipitate was filtered to give 22 mg (70.5%) of the title compound. MS-EI 312 [M+].

1. customThe reaction solution was evaporated to dryness
2. additiontreated with cold ethanol
3. filtrationThe yellow precipitate was filtered