4-(3-Chloro 4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one → HCID 69794691, compound

Participants

Reaction Steps

A mixture of 4-(3-chloro-4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (70 mg, 0.25 mmol), 3,5-dimethyl-4-(3-oxo-3-pyrrolidin-1-yl-propyl)-1H-pyrrole-2-carbaldehyde (64.6 mg, 0.26 mmol) and piperidine (3 drops) in ethanol was stirred at room temperature under nitrogen for 2 days. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 65 mg (51%) of the title compound. 1H NMR (300 MHz, DMSO-d6) δ 13.18 (br s, 1H, NH), 11.61 (br s, 1H, NH), 9.13 (br s, 1H), 8.26 (s, 1H), 7.70 (dd, J=2.4 & 6.9 Hz, 1H), 7.31-7.42 (m, 3H), 3.25 (m, 4H, 2×CH2), 2.63 (t, J=7.5 Hz, 2H, CH2), 2.35 (m, 2H, CH2), 2.31 (s, 3H, CH3), 2.12 (s, 3H, CH3), 1.76 (m, 4H, 2×CH2). MS 509 [M++1].

Provenance & Evidence