Ethanol → 5-[3-Methyl-5-(morpholine-4-carbonyl)-1H-pyrrol-2-ylmethylene]-4-piperidin-1-YL-5,7-dihydro-pyrrolo[2,3-D]pyrimidin-6-one

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Reaction Steps

A mixture of 4-chloro-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (169 mg, 1 mmol), 3-methyl-5-(morpholine-4-carbonyl)-1H-pyrrole-2-carbaldehyde (222 mg, 1 mmol) and piperidine (2 drops) in ethanol (3 mL) was heated to reflux for overnight. The precipitate was collected by vacuum filtration, washed with ethyl acetate/hexane and dried to give 332.2 mg (79%) of the title compound as a yellow solid. MS 423 [M++1].

Provenance & Evidence