Trifluoroacetic acid → n-[(1,3-Dimethylindole-2-carbonyl)valinyl]-3-amino-4-oxo-5-(2'6'-dichlorobenzyloxy)pentanoic acid

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Reaction Steps

A solution of N-[(1,3-Dimethylindole-2-carbonyl)valinyl]-3-amino-4-oxo-5-(2′,6′-dichloro-benzyloxy)pentanoic acid, t-butyl ester (49 mg) in anisole (0.2 mL) and methylene chloride (2 mL) was treated with TFA (1 ml) and stirred for 30 minutes under a nitrogen atmosphere at room temperature. The resultant solution was concentrated and chased with methylene chloride to give a white solid as the crude product. The crude product was triturated with ether to yield the title product as a white powder (34 mg). MS(EI) for C28H31Cl2N3O6; MH+=576/578; (MH)−=574/576.

Provenance & Evidence