HCID 59397908, compound → HCID 59398160, compound

HRID 39745Notes

Reaction equation

HRID 39745 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][NH:13][C:14]3[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=3[N+:22]([O-])=O)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>[C].[Pd].C(O)C>[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][NH:13][C:14]3[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=3[NH2:22])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 59397908HCID 59397908, compound

Product 1

HCID 59398160HCID 59398160, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

To 45 mL of an ethanol solution containing 0.8 g of N-(2-(1,4-dioxaspiro(4.5)decan-8-yl)ethyl)-5-methoxy-2-nitroaniline, 0.25 g of 10% palladium-carbon was added at room temperature, and the mixture was stirred at 40° C. for 3 hours and 30 minutes under a hydrogen atmosphere. The insoluble material filtered off, and the solvent was removed under reduced pressure to obtain 0.81 g of a violet oily substance, 2-(2-(1,4-dioxaspiro(4.5)decan-8-yl)ethyl)amino-4-methoxyaniline.

Workup

  1. additionwas added at room temperature
  2. filtrationThe insoluble material filtered off
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-5ed448ea17884c72a734660556539b2f
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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