反应详情

温度

-78 °C

DMSO (0.60 mL, 8.5 mmol) was added to a methylene chloride solution of oxalyl chloride (2.1 mL, 2.0 M, 4.2 mmol, in 15 mL of methylene chloride), and the resultant reaction mixture was stirred for 10 minutes under a nitrogen atmosphere at −78° C. A methylene chloride solution of N-[(5-fluoro-l-methylindole-2-carbonyl)valinyl]-3-amino-4-hydroxy-5-fluoropentanoic acid, t-butyl ester (820 mg, 1.7 mmol, in 8 mL of dry methylene chloride), and DMSO (0.4 mL) were added dropwise to the reaction mixture and stirred for 15 minutes at −78° C. TEA (1.4 mL, 10.2 mmol) was added to the mixture dropwise and the mixture was stirred for 10 minutes at −78° C., then was allowed to warm to room temperature. The reaction mixture was partitioned between ethyl acetate and 5% KHSO4 solution and the aqueous layer was back-extracted with ethyl acetate. The combined ethyl acetate solutions were washed with 5% KHSO4 solution and brine, dried over sodium sulfate, and concentrated to give the title product as a slightly yellow solid. Trituration with ether afforded the title product as a white powder (705 mg, 85%). TLC: (methanol/methylene chloride, 1:9): Rf=0.63. MS for C24H30CIF2N3O5: MH+=514/516; (M−H)−=512/514.

1. customthe resultant reaction mixture
2. stirringstirred for 15 minutes at −78° C
3. stirringthe mixture was stirred for 10 minutes at −78° C.
4. temperatureto warm to room temperature
5. customThe reaction mixture was partitioned between ethyl acetate and 5% KHSO4 solution
6. extractionthe aqueous layer was back-extracted with ethyl acetate
7. washThe combined ethyl acetate solutions were washed with 5% KHSO4 solution and brine
8. dry with materialdried over sodium sulfate
9. concentrationconcentrated