HCID 59398319, compound → HCID 59398143, compound

HRID 39748Notes

Reaction equation

HRID 39748 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[N+:16]([O-])=O>[C].[Pd].C(O)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][NH:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[NH2:16]

Participants

4

Reactant 1

HCID 59398319HCID 59398319, compound

Product 1

HCID 59398143HCID 59398143, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

To 100 mL of an ethanol suspension containing 4.5 g of N-(1,3-dioxolan-2-ylmethyl)-5-methoxy-2-nitroaniline, 1.3 g of 10% palladium-carbon was added at room temperature, and the mixture was stirred at 40° C. for 3 hours and 40 minutes under a hydrogen atmosphere. The insoluble material filtered off, and the solvent was removed under reduced pressure to obtain 3.5 g of a violet oily substance, 2-(1,3-dioxolan-2-ylmethyl)amino-4-methoxyaniline.

Workup

  1. additionwas added at room temperature
  2. filtrationThe insoluble material filtered off
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-4ec131c15e3d486087635cd7471b4580
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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