HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 397481Generated: October 28, 2026
Sodium Azide → 2-(Azidomethyl)benzonitrile
https://huagongshe.com/reaction/397481
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-(Bromomethyl)benzonitrile | HCID 89599 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(Azidomethyl)benzonitrile | HCID 11491974 | — |
Reaction Steps
To a solution of 90 g (459 mmol) 2-cyanobenzylbromide in 600 mL THF was added in one portion a solution of 36 g (553 mmol) sodium azide in 100 mL water. The two phase mixture was stirred at 23° C. for 18 hr. The THF layer was separated from the lower water layer and used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06610701B2 |
|---|
| Source dataset | uspto-grants-2003_08 |
|---|
| ORD ID | ord-2c867fefb3b547388bbdb43b00d682d7 |
|---|
| Source note | uspto-grants-2003_08 |
|---|
