Hydrochloric Acid → HCID 23000576, compound

Participants

Reaction Steps

To a solution of 0.159 g (0.469 mmol) ethyl {2-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-3-fluoropyridin-4-yl}acetate 29-2 in 1 mL MeOH was added 469 uL (0.469 mmol, 1M aqueous solution) LiOH. The reaction was stirred at room temperature for 23 h. To the reaction was added 38.7 uL (0.469 mmol, 12M aqueous solution) HCl. The mixture was stirred for 10 min, concentrated in vacuo, and placed under vacuum alongside P2O5 to yield {2-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-3-fluoropyridin-4-yl}acetic acid 29-3. 1H NMR (CD3OD, 400 MHz) δ8.606 (d, 1H, J=4.77 Hz, ArH); 7.894 (t, 1H, J=7.83 Hz, ArH); 7.692 (d, 1H, J=7.69 Hz, ArH); 7.609 (d, 1H, J=5.22 Hz, ArH); 7.458 (t, 1H, J=6.05 Hz, ArH); 6.499 (t, 1H, J=4.99 Hz, ArH); 4.324 (t, 2H, J=13.92 Hz, CH2); 3.572 (s, 2H, CH2); MS (Electrospray): m/z 312.0 (M+H).

Provenance & Evidence