Potassium Iodide → HCID 23000344, compound

Participants

Reaction Conditions

Reaction Steps

796 mg of 6-[6-(methanesulfonyloxy)hexylamino][1,2,4]triazolo[4,3-b]pyridazine was dissolved in 15 ml of N,N-dimethylformamide; 769 mg of 1-(diphenylmethyl)piperazine, 422 mg of potassium carbonate, and 506 mg of potassium iodide were added, followed by stirring at 60° C. for 4 hours. After cooling, saline was added; the reaction mixture was extracted with ethyl acetate and dried over magnesium sulfate. After concentration under reduced pressure, the residue was subjected to silica gel column chromatography and eluted with ethyl acetate-methanol-triethylamine (50:5:1). The desired fraction was collected and concentrated under reduced pressure; the residue was crystallized from ethyl acetate, washed with diethyl ether, recrystallized in the same manner, and dried, to yield 353 mg of the title compound.

Provenance & Evidence