Water → HCID 23000302, compound

Participants

Reaction Conditions

Reaction Steps

1.58 g of 4-(diphenylmethoxy)-1-piperidinepropanamine and 1.38 g of N-(6-chloro[1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl)glycine ethyl ester were dissolved in 15 ml of N,N-dimethylformamide; 1.68 ml of N-ethyldiisopropylamine was added, followed by stirring under heating at an external temperature of 70° C. for 5 hours. After cooling, water was added; the reaction mixture was extracted with tetrahydrofuran. After concentration under reduced pressure, the precipitated crystal was twice recrystallized from ethanol-tetrahydrofuran (1:1), collected by filtration, and dried, to yield 995 mg of the title compound.

Provenance & Evidence