Sodium Hydroxide → HCID 23000304, compound

HRID 397570Notes

Reaction equation

HRID 397570 reaction equation
C([O:3][C:4](=[O:42])[CH2:5][NH:6][C:7]([C:9]1[N:13]2[N:14]=[C:15]([NH:18][CH2:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH:25]([O:28][CH:29]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:24][CH2:23]3)[CH:16]=[CH:17][C:12]2=[N:11][N:10]=1)=[O:8])C.[OH-].[Na+]>C(O)C>[C:36]1([CH:29]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:28][CH:25]2[CH2:24][CH2:23][N:22]([CH2:21][CH2:20][CH2:19][NH:18][C:15]3[CH:16]=[CH:17][C:12]4[N:13]([C:9]([C:7]([NH:6][CH2:5][C:4]([OH:42])=[O:3])=[O:8])=[N:10][N:11]=4)[N:14]=3)[CH2:27][CH2:26]2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23000302HCID 23000302, compound

Product 1

HCID 23000304HCID 23000304, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.29 g of N-[6-(3-[4-(diphenylmethoxy)piperidino]propylamino)[1,2,4]triazolo[4,3-b]pyridazine-3-carbonyl]glycine ethyl ester was dissolved in 10 ml of ethanol; 4.5 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 30 minutes. The ethanol was distilled off under reduced pressure; the reaction mixture was adjusted to pH 4.5 using 1 N hydrochloric acid. The precipitated crystal was collected by filtration, washed with water and acetone, and dried, to yield 831 mg of the title compound.

Workup

  1. distillationThe ethanol was distilled off under reduced pressure
  2. filtrationThe precipitated crystal was collected by filtration
  3. washwashed with water and acetone
  4. customdried

Sources & evidence

ORD record
ord-5c44b85b022948358d1f3f0bd10688ff
Source dataset
uspto-grants-2003_08
Patent number
US06610694B1

Reaction notes

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