Butylamine → HCID 23000672, compound

HRID 397596Notes

Reaction equation

HRID 397596 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH:28]3[O:30][CH2:29]3)=[C:22]([CH3:31])[CH:21]=2)[CH:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1.[CH2:32]([NH2:36])[CH2:33][CH2:34][CH3:35]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH:28]([OH:30])[CH2:29][NH:36][CH2:32][CH2:33][CH2:34][CH3:35])=[C:22]([CH3:31])[CH:21]=2)[CH:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 8007ButylamineHCID 12114670HCID 12114670, compound

Product 1

HCID 23000672HCID 23000672, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of (4-methoxyphenyl)-(3-methyl-4-(2,3-epoxypropyloxy)phenyl)-1,2,3,4-tetrahydronaphth-1-yl-methane (300 mg, 0.001 mol), n-butyl amine (1.0 m, 0.01 mol) and ethanol (15 ml) was refluxed for 8 hrs. Ethanol was distilled off and the residue was passed through a basic alumina column using hexane:ethyl acetate as the eluent. Solvent was distilled off to give the title compound. Yield 212 mg, (60.05%).

Workup

  1. temperaturewas refluxed for 8 hrs
  2. distillationEthanol was distilled off
  3. distillationSolvent was distilled off

Sources & evidence

ORD record
ord-852ca2acf639489bac60387c81e61cee
Source dataset
uspto-grants-2003_08
Patent number
US06610705B1

Reaction notes

Loading…