HRID397627

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11063861

1H-Benzo[d]imidazole-2-sulfonyl chloride

C7H5ClN2O2S

结构：Cl.O=C1c2ccccc2C(=O)N1Cc1ccc(OCc2nc([C@@H]3CCCCN3)no2)cc1

HCID69948836

未命名化合物

PRODUCTS

生成物

结构：O=C1c2ccccc2C(=O)N1Cc1ccc(OCc2nc([C@@H]3CCCCN3S(=O)(=O)c3nc4ccccc4[nH]3)no2)cc1

HCID57267114

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by a similar method to Example 1 from 2-[4-(3-[(2S)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione hydrochloride [see Preparation 15] and 1H-benzo[d]imidazole-2-sulfonyl chloride [see Preparation 8] to afford 2-[4-(3-[(2S)-1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione (956 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6b21338586c54d15bc30a628973d4f2a
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06610707B1
来源说明: uspto-grants-2003_08

反应 SMILES

Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]1[N:12]=[C:11]([CH2:13][O:14][C:15]2[CH:32]=[CH:31][C:18]([CH2:19][N:20]3[C:28](=[O:29])[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:21]3=[O:30])=[CH:17][CH:16]=2)[O:10][N:9]=1.[NH:33]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=2[N:35]=[C:34]1[S:42](Cl)(=[O:44])=[O:43]>>[NH:33]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=2[N:35]=[C:34]1[S:42]([N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]1[N:12]=[C:11]([CH2:13][O:14][C:15]2[CH:32]=[CH:31][C:18]([CH2:19][N:20]3[C:21](=[O:30])[C:22]4[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:28]3=[O:29])=[CH:17][CH:16]=2)[O:10][N:9]=1)(=[O:43])=[O:44]