Methylamine hydrochloride → HCID 9934961, compound

HRID 397630Notes

Reaction equation

[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[C:19]1[N:23]=[C:22]([CH2:24][O:25][C:26]2[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=2)[O:21][N:20]=1)(=[O:12])=[O:11].Cl.[CH3:35][NH2:36]>>[NH:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:1]=[C:2]1[S:10]([N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[C:19]1[N:23]=[C:22]([CH2:24][O:25][C:26]2[CH:27]=[CH:28][C:29]([CH2:30][NH:36][CH3:35])=[CH:32][CH:33]=2)[O:21][N:20]=1)(=[O:12])=[O:11]

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 23000729HCID 23000729, compound

Product 1

HCID 9934961HCID 9934961, compound

Procedure

The title compound was prepared by a similar method to Example 13 from 4-(3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzaldehyde [see Preparation 22] and methylamine hydrochloride to afford N-[4-(3-[1l-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-N-methylamine as a white solid.

Sources & evidence

ORD record: ord-b6c670e232b548a29c850d0944e2fe77
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06610707B1

Reaction notes

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