Methylamine → Ammonia

Participants

Reaction Steps

The title compound was prepared by a similar method to Example 11 from 2-[4-(3-[(2S)-1-cyclohexylmethylsulfonyl-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione [see Preparation 23] and methylamine. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 100:0:0 changing to 90:10:1, by volume, dichloromethane:methanol:0.88 aqueous ammonia solution to afford 4-[3-((2S)-1-[cyclohexylmethylsulfonyl]-2-piperidyl)-1,2,4-oxadiazol-5-ylmethoxy]benzylamine as a colourless oil.

Provenance & Evidence