Lawesson's reagent → (2S)-1-[(4-fluorophenyl)sulfonyl]-2-(5-methyl-1,3-thiazol-2-yl)piperidine

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Reaction Steps

The title compound was prepared by a similar method to Example 29 from (2S)-1-[(4-fluorophenyl)sulfonyl]-N2-(2-oxopropyl)-2-piperidinecarboxamide [see Preparation 81] and Lawesson's reagent. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 100:0 changing to 75:25, by volume, hexane:ethyl acetate, in 5% increments, to afford (2S)-1-[(4-fluorophenyl)sulfonyl]-2-(5-methyl-1,3-thiazol-2-yl)piperidine as a white solid.

Provenance & Evidence