Dichloromethane → HCID 69948166, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl (2S)-2-(5-benzyl-1,2,4-oxadiazol-3-yl)-1-piperidinecarboxylate (10.59 g) [see Preparation 6] was dissolved in dichloromethane (150 ml) and cooled to 0° C. Hydrogen chloride gas was then bubbled through until the point of saturation. The reaction mixture was then stirred for 30 mins. at 0° C., the solvent was removed under reduced pressure and the product azeotroped with dichloromethane to afford 5-benzyl-3-[(2S)-2-piperidyl]-1,2,4-oxadiazole hydrochloride (8.3 g) as a yellow solid.

Provenance & Evidence