反应详情

Sodium sulfite heptahydrate (6.10 g) was added to a solution of 3-(bromomethyl)tetrahydrofuran (2.0 g) [see Preparation 9] in 1,4-dioxane (9 ml) and water (9 ml). The reaction mixture was then heated under reflux and stirred for 18 hours, cooled and the solvent removed under reduced pressure. The resulting solid was dissolved in water and concentrated to a low volume. The solid formed was then collected to afford sodium tetrahydrofuran-3-ylmethanesulfonate (1.30 g) as a white solid.

1. temperatureThe reaction mixture was then heated
2. temperatureunder reflux
3. temperaturecooled
4. customthe solvent removed under reduced pressure
5. dissolutionThe resulting solid was dissolved in water
6. concentrationconcentrated to a low volume
7. customThe solid formed
8. customwas then collected