Methyl morpholine oxide → HCID 23000729, compound

Participants

Reaction Steps

Tetrapropylammonium perruthenate (14.4 mg) was added to a stirred suspension of 4-(3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)phenylmethanol (384 mg) [see Preparation 21], N-methylmorpholine oxide (166 mg) and 4 Å molecular sieves in 10% v/v acetonitrile/dichloromethane (4 ml). The reaction mixture was stirred for 1 hour after which time the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica gel eluting with ethyl acetate to afford 4-(3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzaldehyde (342 mg).

Provenance & Evidence