HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (2S)-1-[(cyclohexylmethyl)sulfonyl]-2-piperidinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 57034239 | HCID 57034239 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | (2S)-1-[(cyclohexylmethyl)sulfonyl]-2-piperidinecarbonitrile | HCID 57034946 | — |
Reaction Steps
The title compound was prepared by a similar method to Preparation 3 from (2S)-1-[(cyclohexylmethyl)sulfonyl]-2-piperidinecarboxamide [see Preparation 26], oxalyl chloride, dimethylformamide and pyridine. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 80:20 changing to 20:80, by volume (in 10% increments), hexane:ethyl acetate to afford (2S)-1-[(cyclohexylmethyl)sulfonyl]-2-piperidinecarbonitrile as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610707B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-c75e56e16bf0475492948f8f99c876c0 |
| Source note | uspto-grants-2003_08 |