HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzenesulfonyl chloride → benzyl (2S)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| Reactant | Proline benzyl ester hydrochloride | HCID 2733413 | — |
| Product | benzyl (2S)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxylate | HCID 8957654 | — |
Reaction Steps
The title compound was prepared by a similar method to Example 1 from L-proline benzyl ester hydrochloride and 4-fluorobenzenesulphonyl chloride. The crude product was purified by column chromatography on silica gel eluting with dichloromethane to afford benzyl (2S)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxylate as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610707B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-46b6ae92d7be487fb6a8c5438df2d915 |
| Source note | uspto-grants-2003_08 |