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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 397686Generated: October 25, 2026

4-Methylmorpholine → HCID 59085907, compound

https://huagongshe.com/reaction/397686

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylmorpholineHCID 7972—
Reactant3-(Dimethylamino)propanoic acidHCID 239828—
Reactant1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
ReactantHCID 59085897HCID 59085897—
ReactantHCID 178526939HCID 178526939—
ProductHCID 59085907HCID 59085907—

Reaction Steps

The title compound was prepared by the method of Preparation 5 from (Z)-(2S)-1-[cyclohexylmethylsulfonyl]-N′2-hydroxy-2-piperidinecarboximidamide [see Preparation 28], 3-(dimethylamino)propanoic acid [Papapoulos, et al, WO 9619998A1], N-methyl morpholine, hydroxybenzotriazole hydrate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, to afford (Z)-(2S)-1-[(cyclohexylmethyl)sulfonyl]-N′2-[3-(dimethylamino)propanoyl]oxy-2-piperidinecarboximidamide as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06610707B1
Source datasetuspto-grants-2003_08
ORD IDord-237515ee040e45b2b234be7053388eb5
Source noteuspto-grants-2003_08