HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → [(Z)-[amino-[(2S)-1-(cyclohexylmethylsulfonyl)piperidin-2-yl]methylidene]amino] formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (2S)-1-(cyclohexylmethylsulfonyl)-N'-hydroxypiperidine-2-carboximidamide | HCID 59085897 | — |
| Reactant | HCID 178526939 | HCID 178526939 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | [(Z)-[amino-[(2S)-1-(cyclohexylmethylsulfonyl)piperidin-2-yl]methylidene]amino] formate | HCID 59085934 | — |
Reaction Steps
The title compound was prepared by a similar method to Preparation 5 from (Z)-(2S)-1-[cyclohexylmethylsulfonyl]-N′2-hydroxy-2-piperidinecarboximidamide [see Preparation 28], formic acid, N-methyl morpholine, hydroxybenzotriazole hydrate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, to afford (Z)-(2S)-1-[(cyclohexylmethyl)sulfonyl]-N′2-(formyloxy)-2-piperidinecarboximidamide as a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610707B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-791fcf28bae742699ce7906d3dab081c |
| Source note | uspto-grants-2003_08 |