HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → N'1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | N-Hydroxyacetamidine | HCID 30926 | — |
| Reactant | (2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acid | HCID 768662 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 178526939 | HCID 178526939 | — |
| Product | N'1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide | HCID 86759129 | — |
Reaction Steps
The title compound was prepared by a similar method to Preparation 39 from (2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acid [see Preparation 38], N′1-hydroxyethanimidamide [La Manna, et al, Theochem (1990), 69, 161-68], N-methyl morpholine, hydroxybenzotriazole hydrate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, to afford N′1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide as a colourless gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610707B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-e7677b96e87e47b1a7b81a6c1509a510 |
| Source note | uspto-grants-2003_08 |