HCID 23000733, compound → HCID 23000725, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl N-(3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethyl)carbamate (0.88 g) [see Preparation 85] was dissolved in dioxan (20 ml) and cooled to 0° C. Hydrogen chloride gas was then bubbled through for 10 mins. The reaction mixture was then stirred at room temperature for 1 hr. the solvent was then removed under reduced pressure to afford 3-[1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethylamine (0.67 g) as the hydrochloride salt as a white solid.

Provenance & Evidence