反应详情

The title compound was prepared by a similar method to Preparation 13 from (Z)-(2S)-2-[amino([2-(1-[(benzyloxy)carbonyl]-4-piperidyloxy)acetyl]oxyimino)methyl]-1-piperidinecarboxylate [see Preparation 93] and pyridine. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 80:20, changing to 50:50, by volume, hexane:ethyl acetate, in 5% increments, to afford tert-butyl (2S)-2-{5-[(1-[(benzyloxy)carbonyl]-4-piperidyloxy)methyl]-1,2,4-oxadiazol-3-yl}-1-piperidinecarboxylate.

1. customThe crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 80:20