tert-butyl (2S)-2-[(Z)-N'-[(2R)-2-phenyl-2-(phenylmethoxycarbonylamino)acetyl]oxycarbamimidoyl]piperidine-1-carboxylate → tert-butyl (2S)-2-{5-[(R)-{[(benzyloxy)carbonyl]amino}(phenyl)methyl]-1,2,4-oxadiazol-3-yl}-1-piperidinecarboxylate

Participants

Reaction Steps

The title compound was prepared by a similar method to Preparation 6 from tert-butyl (2S)-2-[(Z,5R)-1-amino-4,7-dioxo-5,9-diphenyl-3,8-dioxa-2,6-diaza-1-nonen-1-yl]-1-piperidinecarboxylate [see Preparation 10 1] and pyridine to afford tert-butyl (2S)-2-{5-[(R)-{[(benzyloxy)carbonyl]amino}(phenyl)methyl]-1,2,4-oxadiazol-3-yl}-1-piperidinecarboxylate as an oil.

Provenance & Evidence