Pyridine → HCID 23001032, compound

Participants

Reaction Steps

To 4-(3-aminophenyl)-N-hexyl-4-methylpiperidine (Preparation 56, 70.0 mg, 0.27 mmol) in dichloromethane (3 ml) was added methanesulfonyl chloride (61 mg, 0.53 mmol) in dichloromethane (0.5 ml) and pyridine (42 mg, 0.53 mmol) in dichloromethane (0.5 ml) at room temperature. The solution was stirred at room temperature for 16 h, then it was concentrated in vacuo to give the crude product. This was purified by silica column chromatography eluting with a gradient of ethyl acetate:hexane:0.88 ammonia (90:10:1 to 98:2:1) to give the title compound as a colourless oil (65 mg, 72%).

Provenance & Evidence