Pyridine → HCID 54458887, compound

Participants

Reaction Steps

To 4-(3-aminophenyl)-N-hexyl-4-methylpiperidine (Preparation 56, 72.0 mg, 0.26 mmol) in dichloromethane (1 ml) was added n-propanesulfonyl chloride (75 mg, 0.53 mmol) in dichloromethane (1 ml) and pyridine (42 mg, 0.53 mmol) in dichloromethane (1 ml) at room temperature. The solution was stirred at room temperature for 20 h, then it was concentrated in vacuo to give the crude product. This was purified by silica column chromatography eluting with ethyl acetate:0.880 ammonia (100:1) to give the title compound as a colourless oil (80 mg, 80%).

Provenance & Evidence