Hydrochloric Acid → HCID 23000931, compound

Participants

Reaction Steps

To a solution of N-hexyl-4-methyl-4-(3-diphenylmethylideneaminophenyl)piperidine (Preparation 55, 112 mg, 0.26 mmol) in tetrahydrofuran (4 ml) was added 2N aqueous hydrochloric acid (1 ml) and the mixture was stirred at room temperature for 30 min. The mixture was concentrated in vacuo, 2N aqueous hydrochloric acid (3 ml) was added and the aqueous phase was extracted with hexane:ethyl acetate (2:1, 5 ml). The aqueous layer was then basified with 2N aqueous sodium hydroxide solution and extracted with dichloromethane (3×10 ml). The combined extracts of the basic aqueous layer were dried (MgSO4), filtered and concentrated in vacuo to give the title compound which was used without further purification (70 mg, 99% crude yield).

Provenance & Evidence