HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tos-lys(boc)-OH → (2S)-6-[[(2S)-6-amino-2-(p-tolylsulfonylamino)hexanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tos-lys(boc)-OH | HCID 3013735 | — |
| Reactant | (2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 3013742 | — |
| Product | (2S)-6-[[(2S)-6-amino-2-(p-tolylsulfonylamino)hexanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508562 | — |
Reaction Steps
The title compound was prepared from solid phase bound Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-Nε-(9-fluorenylmethoxycarbonyl)-L-lysine as described in general procedure Bb using Nα-(4-methylbenzenesulfonyl)-Nε-tert-butoxycarbonyl-L-lysine (360 mg, 1.2 mmol) prepared in step A of this example. The final product was purified by preparative HPLC to yield 10 mg (12%) of the desired material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610689B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-d1dda5c41cdd4b8b9a566c9b74fcdeaf |
| Source note | uspto-grants-2003_08 |