HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl-L-phenylalanine → (2S)-6-[[(2S)-2-benzamido-3-phenyl-propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl-L-phenylalanine | HCID 97370 | — |
| Reactant | (2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 3013742 | — |
| Product | (2S)-6-[[(2S)-2-benzamido-3-phenyl-propanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508573 | — |
Reaction Steps
The title compound was prepared from solid phase bound Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-Nε-(9-fluorenylmethoxycarbonyl)-L-lysine as described in general procedure Bb using Nα-benzoyl-L-phenylalanine (321 mg, 1.2 mmol). The final product was purified by preparative HPLC to yield 44 mg (58%) of the desired material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610689B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-cb93c1e1fd2a4893ae02ab5e07b471f2 |
| Source note | uspto-grants-2003_08 |