Methanol → Methyl 2-phenoxybenzoate

HRID 397817Notes

Reaction equation

HRID 397817 reaction equation
S(Cl)(Cl)=O.[O:5]([C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:21]O>>[CH3:21][O:15][C:14](=[O:16])[C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=1[O:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 752372-Phenoxybenzoic acid

Product 1

HCID 607606Methyl 2-phenoxybenzoate

Conditions

Temperature
70 °C

Procedure

Thionyl chloride (2.0 ml, 28.0 mmol) was added dropwise to a solution of 2-phenoxybenzoic acid (5.0 g, 23.3 mmol) in methanol (70 ml). The reaction mixture was stirred at 70° C. for 3 hours. The solvent was removed in vauco. The crude product was used in the next step without further purification.

Workup

  1. customThe solvent was removed in vauco
  2. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-e60b39cb642d430faa8b318e43e034c3
Source dataset
uspto-grants-2003_08
Patent number
US06610721B2

Reaction notes

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