HCID 23001237, compound → HCID 178506171, compound

Participants

Reaction Conditions

Reaction Steps

A solution of a mixture of 5-(2-chloro-5-trifluoromethylbenzyloxymethyl)-1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazole and 5-(2-chloro-5-trifluoromethylbenzyloxymethyl)-3-triphenylmethyl-4,5,6,7-tetrahydro-3H-benzimidazole in a mixture of acetic acid (5 ml) and water (0.6 ml) was heated to 90° C. for 2 hours. The reaction mixture was cooled to room temperature. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (40 g), using a mixture of DCM/methanol/25% aqueous ammonia (100:10:1) as eluent, to give 310 mg of the title compound.

Provenance & Evidence