HCID 23001254, compound → HCID 178420089, compound

Participants

Reaction Conditions

Reaction Steps

A solution of a mixture of 5-((biphenyl-4-yl)methoxymethyl)-1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazole and 5-((biphenyl-4-yl)methoxymethyl)-3-triphenylmethyl-4,5,6,7-tetrahydro-3H-benzimidazole (440 mg, 0.78 mmol) in a mixture of acetic acid (5 ml) and water (0.6 ml) was heated to 90° C. for 2.25 hours. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (40 g), using DCM/methanol/25% aqueous ammonia (100:10:1) as eluent, to give 220 mg of the title compound.

Provenance & Evidence