HCID 23001243, compound → HCID 178506163, compound

Participants

Reaction Conditions

Reaction Steps

A solution of a mixture of 5-(2-chloro-3-(trifluoromethyl)benzyloxymethyl)-1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazole and 5-(2-chloro-3-(trifluoromethyl)benzyloxymethyl)-3-triphenylmethyl-4,5,6,7-tetrahydro-3H-benzimidazole in a mixture of acetic acid (9 ml) and water (1 ml) was heated to 70° C. for 2 hour. The reaction mixture was cooled to room temperature. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (40 g), using a mixture of DCM/methanol/25% aqueous ammonia (100:10:1) as eluent, to give 25 mg of the title compound.

Provenance & Evidence