Acetic Acid → HCID 178478216, compound

Participants

Reaction Conditions

Reaction Steps

A soution of a mixture of 5-[2-(2,4-dichlorophenoxy)benzyloxymethyl]-1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazole and 5-[2-(2,4-dichlorophenoxy)benzyloxymethyl]-3-triphenylmethyl-4,5,6,7-tetrahydro-3H-benzimidazole (356 mg, 0.55 mmol) in a mixture of glacial acetic acid (9 ml) and water (1 ml) was heated to 70° C. for 2 hours. The reaction mixture was cooled to room temperature. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (80 g), using DCM/methanol/−25% aqueous ammonia as eluent, to give 175 mg of the title compound. HPLC method C: elution at 11.42 min.

Provenance & Evidence