HCID 23001253, compound → HCID 178506383, compound

Participants

Reaction Conditions

Reaction Steps

A solution of a mixture of 5-[2-(3-(trifluoromethoxy)phenoxy)benzyloxymethyl]-1-triphenylmethyl-4,5,6,7-tetrahydro-1H-benzimidazole and 5-[2-(3-(trifluoromethoxy)phenoxy)benzyloxymethyl]-3-triphenylmethyl-4,5,6,7-tetrahydro-3H-benzimidazole (600 mg, 0.91 mmol) in a mixture of acetic acid (9 ml) and water (1 ml) was heated to 70° C. for 2 hours. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (60 g), using DCM/methanol/−25% aqueous ammonia as eluent, to give 251 mg of the title compound.

Provenance & Evidence