HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylimidazole → 2-(3,4-Dichloro-phenyl)-4-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Reactant | 4-Chloromethyl-2-(3,4-dichloro-phenyl)-pyridine hydrochloride | HCID 23445010 | — |
| Product | 2-(3,4-Dichloro-phenyl)-4-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride | HCID 23445169 | — |
Reaction Steps
The title compound, MS: m/e=317.0 (M+) was obtained as a beige solid (51% yield) by the reaction of 4-chloromethyl-2-(3,4-dichloro-phenyl)-pyridine hydrochloride (1:1) with 2-methylimidazole, using sodium hydride and triethylamine as base followed by formation of the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610723B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-8949b727656745398a9d7d5aeef2c521 |
| Source note | uspto-grants-2003_08 |