2-(4-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 3-(4-Chloro-3-methyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride

HRID 397879Notes

Reaction equation

HRID 397879 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])[CH:7]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19](B2OC(C)(C)C(C)(C)O2)=[CH:18][C:17]=1[CH3:31]>>[ClH:15].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH2:8][N:9]3[CH:13]=[CH:12][N:11]=[C:10]3[CH3:14])[CH:7]=2)=[CH:18][C:17]=1[CH3:31]

Participants

3

Reactant 2

HCID 37676412-(4-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 234449653-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine

Product 1

HCID 234450523-(4-Chloro-3-methyl-phenyl)-5-(2-methyl-imidazol-1-yl-methyl)-pyridine Hydrochloride

Procedure

The title compound, MS: m/e=298.3 (M+H+) was obtained as a white solid (73% yield) by the reaction of 3-bromo-5-(2-methyl-imidazol-1-yl-methyl)-pyridine with 2-(4-chloro-3-methyl-phenyl)-4,4,5,5-tetramethyl[1,3,2]-dioxaborolane.

Sources & evidence

ORD record
ord-ca2f49b5ce2f4fd4b35e1cfc2b590ffa
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Reaction notes

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