Acetic Acid → HCID 23444955, compound

Participants

Reaction Steps

A solution of {1-[1-(3,4-dichloro-phenyl)-1H-imidazol-4-ylmethyl]-1H-imidazol-2-yl}-methyl-amine (0.60 g, 1.7 mmol) in acetic acid (7 ml) and aqueous formaldehyde (2 ml of a 37% solution) was stirred at 20° C. for 96 h. The reaction mixture was evaporated to dryness and chromatographed [silica, elution with gradient CH2Cl2 to 50% (CH2Cl2/MeOH/aq. NH4OH=90:10:1)] to obtain the free base of the title compound. It was crystallized as the off-white hydrochloride salt (0.030 g, 5%). Mp.>180° C. dec. (MeOH/Et2O), MS: m/e=352 (M+H+).

Provenance & Evidence