HuagongsheHuagongshe Chemistry Print Report · For research reference only
lithium aluminium hydride THF → [4-(3,4-Dichlorophenyl)-2-pyridinyl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | lithium aluminium hydride THF | HCID 68718528 | — |
| Reactant | 4-(3,4-Dichloro-phenyl)-pyridine-2-carboxylic acid methyl ester | HCID 69038928 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [4-(3,4-Dichlorophenyl)-2-pyridinyl]methanol | HCID 23445021 | — |
Reaction Steps
The title compound, MS: m/e=252.0 ([M-H]-) was obtained as a light brown oil (94% yield) by the reaction of 4-(3,4-dichloro-phenyl)-pyridine-2-carboxylic acid methyl ester with 1M lithium aluminum hydride/THF solution in THF at 20° C. for 1 h followed by chromatographic purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610723B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-f7c67394ff0d442089f178456d1b579e |
| Source note | uspto-grants-2003_08 |