HCID 23444959, compound → 445303-18-4

HRID 397917Notes

Reaction equation

HRID 397917 reaction equation
[F:1][C:2]([C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:6]=1[F:14])([F:4])[CH3:3]>CO>[F:4][C:2]([C:5]1[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:6]=1[F:14])([F:1])[CH3:3]

Participants

3

Reactant 1

HCID 23444959HCID 23444959, compound

Product 1

HCID 23445006445303-18-4

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-(1,1-difluoro-ethyl)-1-fluoro-4-nitro-benzene (10.4 g, 50.6 mmol) in methanol (200 ml) palladium on carbon (10%, 4 g) was added and the resulting mixture was hydrogenated for 2 h at 20° C. After filtration of the catalyst the solvent was evaporated to yield the title compound as a yellow semi solid mass. (8.5 g, 96%). MS: m/e=175 (M+).

Workup

  1. filtrationAfter filtration of the catalyst the solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-91f15c36b62f4479a0122d0f5d63f4cb
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Reaction notes

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